WebbLeaving academic research and embarking on a new career in industry was and still is challenging! I would like to thank all mentors in academia and at my new company for their support along the way! In my new position at Cytosurge, I am combining my skills in molecular cell biology, stem cells and developmental biology with the cutting-edge … Webb9 apr. 2024 · It also controls cell proliferation in response to cell contact, where the TEAD family are required for YAP-dependent gene expression . The TEAD family of transcriptional enhancer factors, also known as TEA domain family, is also required for YAP-induced cell growth, oncogenic transformation, and epithelial-mesenchymal transition induction [ 41 ].
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Webbin the SV40 enhancer and in the promoter regions of TEAD target genes.1,11-13 The C-terminal region of TEAD adopts an immunoglobulin-like β-sandwich fold (Fig. 1C).14 This domain recruits transcription coactivators and therefore could be consid-ered as a “transactivation” domain. TEAD on its own is unable Webb14 apr. 2024 · Abstract. The YAP-TEAD protein-protein interaction (PPI) is a critical event known to mediate YAP oncogenic functions downstream of the Hippo pathway. Current advanced pharmacological agents which aim at inhibiting YAP-TEAD oncogenic function do so by engaging into the lipid pocket of TEAD. Thereby the consequences of a direct … daley\u0027s cheap shots spokane valley
American Association for Cancer Research
Webb2 jan. 2024 · Hippo signaling restricts tumor growth by inhibiting the oncogenic potential of YAP/TAZ-TEAD transcriptional complex. Here, we uncover a context-dependent tumor suppressor function of YAP in androgen receptor (AR) positive prostate cancer (PCa) and show that YAP impedes AR + PCa growth by antagonizing TEAD-mediated AR signaling. … Webb8 feb. 2024 · Chromatin immunoprecipitation identified enhancers associated with myogenic genes bound by combinations of Tead4, Myod1 or Myog. Tead4 regulated … Webbab58310 has been referenced in 66 publications. Yu T et al. Nuclear TEAD4 with SIX1 Overexpression is an Independent Prognostic Marker in the Stage I-III Colorectal Cancer. Cancer Manag Res 13:1581-1589 (2024). PubMed: 33628048; Zhong C et al. Remodeling cancer stemness by collagen/fibronectin via the AKT and CDC42 signaling pathway … bipartisan immigration reform 2022