WitrynaNo standard treatment has been established for metastatic uveal melanoma (mUM). Immunotherapy is commonly used for this disease even though UM has not been included in phase III clinical trials with checkpoint inhibitors. Unfortunately, only a minority of patients obtain a clinical benefit with immunotherapy. The immunological features … Witryna12 kwi 2024 · Advances in immunotherapy including the use of monoclonal antibodies, immune checkpoint inhibitors, cancer vaccines, and cell-based therapies have given much-needed hope to cancer patients. ... medical oncologist and Associate Professor, Director of the Uveal Melanoma Program, and Melanoma Fellowship Program …
Clinical Trials in Metastatic Uveal Melanoma: Immunotherapy
WitrynaBetter treatment for metastatic uveal melanoma would be an important advance, since checkpoint immunotherapy has activity but is less effective in this melanoma … WitrynaUveal melanoma (UM) is the most common primary cancer of the eye and is associated with a high rate of metastatic death. ... UM is an immunoresistant tumor type that responds poorly to checkpoint-inhibitor immunotherapy [10]. This is due, at least in part, to a suppressive tumor immune microenvironment (TIME), including an enrichment of … chinese zodiac years 1965
PRAME as a Potential Target for Immunotherapy in Metastatic …
Witryna30 paź 2024 · PURPOSE Metastatic uveal melanoma has poor overall survival (OS) and no approved systemic therapy options. Studies of single-agent immunotherapy … Witryna1 cze 2024 · Importance: Uveal melanoma (UM) is an intraocular primary malignant neoplasm that often gives rise to metastatic disease for which there are no effective … Witryna23 mar 2024 · However, the clinical relevance of glycosylation-related genes (GRGs) in uveal melanoma (UM) is yet to be fully understood. This study aimed to shed light on the impact of GRGs on UM prognosis. Methods: To identify the most influential genes in UM, we employed the AUCell and WGCNA algorithms. The GRGs signature was … grangemouth tank wash