WebFeb 9, 2024 · Identification of ISG candidates by microarray analysis. To identify ISG candidates, we used Con-IFN to treat three human immune cell lines, CD4 + T-cell-derived CEM, monocyte-derived U937 and B cell … WebSep 1, 2024 · Although FUBP1 loss led to cell-type-specific AS of target genes, we observed that 8.5% of FUBP1-target genes are conserved among the AS events in both mammary epithelium and brain. This frequency is similar to the rate of FUBP1-target genes conserved between siFUBP1-U87MG cell line and primary glioma tumors with FUBP1 …
Identification of FUBP1 as a Long Tail Cancer Driver and …
WebFeb 6, 2015 · FUBP1 also has functions in RNA metabolism as a member of the AU-rich element (ARE) binding protein family (translation or stabilization of several cellular and viral mRNA species) (review in ). Thus, by binding to DNA and RNA, FUBP1 modulates gene expression, regulates mRNA stability and functions as an ATP-dependent DNA helicase. WebMay 1, 2013 · FUBP1 is a transcriptional regulator and fulfills an important function in the precise control of c-myc transcription (mechanism described below). The c-Myc protein is a transcription factor which regulates the transcription of many different target genes that play a role in proliferation, cell cycle progression, differentiation, apoptosis and cell metabolism. magazine gun parts
The transcriptional regulator FUBP1 influences …
WebJan 11, 2024 · The far upstream element (FUSE) binding protein 1 (FUBP1) is a single strand DNA and RNA binding factor that controls mRNA transcription of its target genes [1, 2].FUBP1 functions as a ... WebThe protein encoded by this gene is a single stranded DNA-binding protein that binds to multiple DNA elements, including the far upstream element (FUSE) located … WebJun 11, 2024 · Mutations in the FUBP1 gene and loss of function are frequently found in patients with central nervous system diseases and intestinal cancer [17, 31]. Whereas, overexpression of FUBP1 is also often appears in various cancers including breast cancer, gastric cancer, hepatocellular carcinoma, nasopharyngeal carcinoma and leukemia [ 19 , … magazine gun