WebApr 11, 2024 · Fig. 1: Main design for diverse terpene synthesis. Starting from differently functionalized — but generally simple — phenols, our strategy for terpene synthesis … WebJan 25, 2024 · In all of these cases, access to novel terpenoid derivatives or more efficient synthesis of complex terpenoids could be obtained, demonstrating the power and utility of this approach, especially when combined with contemporary tools in organic synthesis. ... Divergent synthesis of complex diterpenes via a hybrid oxidarive approach. Science,
Divergent Synthesis and Chemical Reactivity of Bicyclic …
WebMar 1, 2024 · Furthermore, regio- and stereoselective installation of various oxygenated functional groups constitutes another formidable challenge for the total synthesis of these diterpenoids. 27 Herein, we describe our implementation of such an intriguing two-phase strategy 28, 29 by merging divergent ring-formation strategy with diverse late-stage C–H ... WebAug 14, 2024 · Nature's ability to efficiently biosynthesize diterpenoids has attracted chemists to mimic it for the synthesis of complex diterpenoids using either pure … imovie how to pop up pic wit sound
Divergent synthesis of complex diterpenes through a …
WebDivergent Synthesis of Complex ent-Kauranes, ent-Atisanes and ent-Trachylobanes via a Hybrid Oxidative Approach. Working Paper ... Show author details … WebMar 16, 2024 · Abstract. With complex molecular architectures, intriguing oxidation patterns, and wide-ranging biological activities, diterpene natural products have greatly impacted research in organic chemistry and drug discovery. Our laboratory has completed total syntheses of several highly oxidized diterpenes, including the ent -kauranoids … WebMar 11, 2024 · Herein, we report a divergent synthesis of wickerols A and B in 16 and 15 steps, respectively, from commercial sitolactone. The key reactions of the synthesis are a SmI 2 -mediated intramolecular ketone-allylic acetate reductive cyclization, a Claisen rearrangement, and an intramolecular alkylation/aldol reaction that rapidly assembled the ... imovie how to trim video