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WebCommon Questions and Answers about Can i take phentermine with metformin phentermine My doctor said it could be the phentermine but that the metformin xr … WebDrug interactions are reported among people who take Phentermine and Metformin. Common interactions include fatigue among females and chronic kidney disease among … WebDec 31, 2009 · 12-29-2009, 01:21 PM. I took Metformin (500mg) and Phentermine (37.5) together for about a year and a half. They are perfectly fine to take together as far as OBVIOUS side effects go; no vomiting, no racing heart, or anything like that. the quark structure of hadrons